Mortality from Parkinson's disease: A population‐based prospective study (NEDICES)
Identifieur interne : 000238 ( Main/Exploration ); précédent : 000237; suivant : 000239Mortality from Parkinson's disease: A population‐based prospective study (NEDICES)
Auteurs : Ignacio J. Posada [Espagne] ; Julián Benito-Le N [Espagne] ; Elan D. Louis [États-Unis] ; Rocío Trincado [Espagne] ; Alberto Villarejo [Espagne] ; María José Medrano [Espagne] ; Félix Bermejo-Pareja [Espagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2011-12.
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Abstract
Most studies of mortality in Parkinson's disease have been clinical studies, yielding results that are not representative of the general population. We assessed the risk of mortality from Parkinson's disease in the Neurological Disorders in Central Spain (NEDICES) study, a prospective population‐based study in which Parkinson's disease patients who were not ascertained through medical practitioners were also included. The cohort consisted of 5262 elderly subjects (mean baseline age, 73.0 years), including 81 with Parkinson's disease at baseline (1994–1995). Thirteen‐year mortality was assessed. Two thousand seven hundred and one of 5262 subjects (51.3%) died over a median follow‐up of 12.0 years (range, 0.04–14.8 years), including 66 of 81 subjects (81.5%) with Parkinson's disease at baseline and 2635 of 5181 subjects (50.8%) without Parkinson's disease at baseline. In an unadjusted Cox model, the hazard ratio of mortality was increased in subjects with Parkinson's disease (hazard ratio, 2.29; 95% confidence interval, 1.80–2.93; P < .001) versus subjects without Parkinson's disease (reference group). In a Cox model that adjusted for a variety of demographic factors and comorbidities, the risk of mortality remained elevated in subjects with Parkinson's disease (hazard ratio, 1.75; 95% CI, 1.32–2.31, P < .001). In additional Cox models, Parkinson's disease patients with dementia had particularly high risks of mortality (adjusted hazard ratio, 2.62; 95% CI, 1.40–4.90; P < .001). In this prospective population‐based study, Parkinson's disease was an independent predictor of mortality in the elderly. Parkinson's disease patients with dementia had particularly high risks of mortality. © 2011 Movement Disorder Society
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DOI: 10.1002/mds.23921
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-12">2011-12</date><biblScope unit="volume">26</biblScope><biblScope unit="issue">14</biblScope><biblScope unit="page" from="2522">2522</biblScope><biblScope unit="page" to="2529">2529</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">BB974B5A59EFFA3263E9F391A4F0785C6B58D23F</idno><idno type="DOI">10.1002/mds.23921</idno><idno type="ArticleID">MDS23921</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>elderly</term><term>epidemiology</term><term>mortality</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Most studies of mortality in Parkinson's disease have been clinical studies, yielding results that are not representative of the general population. We assessed the risk of mortality from Parkinson's disease in the Neurological Disorders in Central Spain (NEDICES) study, a prospective population‐based study in which Parkinson's disease patients who were not ascertained through medical practitioners were also included. The cohort consisted of 5262 elderly subjects (mean baseline age, 73.0 years), including 81 with Parkinson's disease at baseline (1994–1995). Thirteen‐year mortality was assessed. Two thousand seven hundred and one of 5262 subjects (51.3%) died over a median follow‐up of 12.0 years (range, 0.04–14.8 years), including 66 of 81 subjects (81.5%) with Parkinson's disease at baseline and 2635 of 5181 subjects (50.8%) without Parkinson's disease at baseline. In an unadjusted Cox model, the hazard ratio of mortality was increased in subjects with Parkinson's disease (hazard ratio, 2.29; 95% confidence interval, 1.80–2.93; P < .001) versus subjects without Parkinson's disease (reference group). In a Cox model that adjusted for a variety of demographic factors and comorbidities, the risk of mortality remained elevated in subjects with Parkinson's disease (hazard ratio, 1.75; 95% CI, 1.32–2.31, P < .001). In additional Cox models, Parkinson's disease patients with dementia had particularly high risks of mortality (adjusted hazard ratio, 2.62; 95% CI, 1.40–4.90; P < .001). In this prospective population‐based study, Parkinson's disease was an independent predictor of mortality in the elderly. Parkinson's disease patients with dementia had particularly high risks of mortality. © 2011 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Espagne</li><li>États-Unis</li></country><region><li>Communauté de Madrid</li><li>État de New York</li></region><settlement><li>Madrid</li><li>New York</li></settlement><orgName><li>Université Columbia</li></orgName></list><tree><country name="Espagne"><noRegion><name sortKey="Posada, Ignacio J" sort="Posada, Ignacio J" uniqKey="Posada I" first="Ignacio J." last="Posada">Ignacio J. Posada</name></noRegion><name sortKey="Benito E N, Julian" sort="Benito E N, Julian" uniqKey="Benito E N J" first="Julián" last="Benito-Le N">Julián Benito-Le N</name><name sortKey="Benito E N, Julian" sort="Benito E N, Julian" uniqKey="Benito E N J" first="Julián" last="Benito-Le N">Julián Benito-Le N</name><name sortKey="Benito E N, Julian" sort="Benito E N, Julian" uniqKey="Benito E N J" first="Julián" last="Benito-Le N">Julián Benito-Le N</name><name sortKey="Bermejo Areja, Felix" sort="Bermejo Areja, Felix" uniqKey="Bermejo Areja F" first="Félix" last="Bermejo-Pareja">Félix Bermejo-Pareja</name><name sortKey="Bermejo Areja, Felix" sort="Bermejo Areja, Felix" uniqKey="Bermejo Areja F" first="Félix" last="Bermejo-Pareja">Félix Bermejo-Pareja</name><name sortKey="Bermejo Areja, Felix" sort="Bermejo Areja, Felix" uniqKey="Bermejo Areja F" first="Félix" last="Bermejo-Pareja">Félix Bermejo-Pareja</name><name sortKey="Medrano, Maria Jose" sort="Medrano, Maria Jose" uniqKey="Medrano M" first="María José" last="Medrano">María José Medrano</name><name sortKey="Posada, Ignacio J" sort="Posada, Ignacio J" uniqKey="Posada I" first="Ignacio J." last="Posada">Ignacio J. Posada</name><name sortKey="Trincado, Rocio" sort="Trincado, Rocio" uniqKey="Trincado R" first="Rocío" last="Trincado">Rocío Trincado</name><name sortKey="Trincado, Rocio" sort="Trincado, Rocio" uniqKey="Trincado R" first="Rocío" last="Trincado">Rocío Trincado</name><name sortKey="Villarejo, Alberto" sort="Villarejo, Alberto" uniqKey="Villarejo A" first="Alberto" last="Villarejo">Alberto Villarejo</name><name sortKey="Villarejo, Alberto" sort="Villarejo, Alberto" uniqKey="Villarejo A" first="Alberto" last="Villarejo">Alberto Villarejo</name></country><country name="États-Unis"><region name="État de New York"><name sortKey="Louis, Elan D" sort="Louis, Elan D" uniqKey="Louis E" first="Elan D." last="Louis">Elan D. Louis</name></region><name sortKey="Louis, Elan D" sort="Louis, Elan D" uniqKey="Louis E" first="Elan D." last="Louis">Elan D. Louis</name><name sortKey="Louis, Elan D" sort="Louis, Elan D" uniqKey="Louis E" first="Elan D." last="Louis">Elan D. Louis</name><name sortKey="Louis, Elan D" sort="Louis, Elan D" uniqKey="Louis E" first="Elan D." last="Louis">Elan D. Louis</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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